12 Things That Can Make You Fail A Drug Test

Daniel Miller avatar
Daniel Miller, Ph.D, Drug Testing Specialist

Last updated on Jan 13, 2024

Failing a drug test is not exclusive to people who usually use drugs only. There are various products that, when consumed, will lead to a false positive in a drug test. Discussed here are twelve things that can make a person fail a drug test:

1. Vitamin B Supplements DON’T cause false positives!

Vitamin B12 is essential for properly functioning and developing organs like the brain, blood cells, nerves, and other vital organs of the human body.

Vitamin B2 makes your urine yellow. This can help you to restore urine color on a drug test.

That’s the only effect vitamin B has on a drug test. It is safe to use during the drug test.

Read this: Ultimate Guide to Passing Any Drug Test

2. Ibuprofen

This is a non-steroidal anti-inflammatory drug (NSAID) and a painkiller that most people prefer to use to relieve pain. Using this painkiller could lead to a positive test for barbiturates, Tetrahydrocannabinol, or Phencyclidine.

This is because Ibuprofen could contain substances like Sertraline and oxaprozin that have been identified as agents that have cross-reactivity with benzodiazepines to release components present in the three forms of drugs aforementioned, and micro components like cannabinoid which are the principal psychoactive constituent of cannabis, highly lipophilic agents like diazepam, which can be detected in urine.

However, some evidence suggests that compounds with chemical structure differences, such as midazolam, chlordiazepoxide, and flunitrazepam, are not detected in many assays.

3. Poppy Seed Bagels


Poppy seeds are often thought to contain morphine, but in actuality, they do not. But during harvesting, they can absorb or be coated by opium extract, which is composed of approximately 12 percent morphine.

Morphine can be detected in the urine up to 48 hours after ingestion of poppy seeds and their by-products. Eating bagels containing poppy seeds as an ingredient raises the chance of morphine in urine, which will lead to a failed drug test.

4. Granola Bars

Granola bars contain hemp seeds as an ingredient. Hemp seeds contain low levels of THC.

Depending on the number of bars consumed, one could test positive for a drug test conducted for tetrahydrocannabinol, the active ingredient in marijuana.

5. Tonic Water

This carbonated soft drink contains quinine dissolved in it. Quinine was initially used for medical purposes to treat malaria and babesiosis.

It is also used in cutting illegal drugs like heroin because of its bitter taste, which complements the bitter taste of heroin.

Cases where quinine has been determined to be present in tonic water, have resulted in positive urine tests for heroin and cocaine drugs.

6. Cold Remedies

Colds prompt most people into consuming over-the-counter products (OTC) to remedy them.

There are many cold remedies, and here are a few that might lead to a failed drug test: Advil has Ibuprofen, which may lead to positive tests conducted for Marijuana.

It might also test positive for Benadryl antihistamine that causes drowsiness and possibly a false positive for PCP.

Bayer Caplets cause false positives for Amphetamines.

Claratin has the active ingredient Loratadine and Pseudoephedrine Sulfate, which shows incorrect positive results for Morphine.

Travis D consists of multiple generic medications, including Phenylpropanolamine, leading to a positive test for Ecstasy.

7.Pizza and pastries


These delicacies contain yeast, which makes the dough rise by fermentation of the various ingredients.

One of the ingredients is sugar, whose byproduct of fermentation is alcohol. Though the alcohol content in these products can be close to minimal, if a breathalyzer test is conducted just a few minutes after eating pizza, one might test positive for alcohol, which is a false-positive result.

8. Antibiotics

Antibiotics are usually prescribed medications. A number of them can trigger a false positive urine drug screen (UDS) tests.

Examples are amoxicillin and ampicillin. When a person ingests these antibiotics, they will be absorbed into the body system, and their ingredients might lead to a false positive test for heroin and cocaine.

9. Baby soap

Ingredients of baby soap may impact drug tests for marijuana, which may lead to a false positive. These ingredients include polyquaternium-11 and Cocamidopropyl betaine.

Researches have not yet established why these chemicals interfere with drug tests and are still in the process of investigating. However, some assumptions try to explain this phenomenon, and there are some compounds in the soap that have a structure that may be similar to THC, or it could be that chemicals in the soap alter how the test works.

10. HIV medication

People living with HIV have efavirenz treatment as one form of medication. Efavirenz is an antiretroviral drug that can lead to false-positive tests for benzodiazepines.

This is due to the structural similarity between efavirenz and benzodiazepines.

Benzodiazepines may have a similar chemical structure with marijuana; hence a person who consumes efavirenz could test positive for marijuana drug tests.

11. Diet Pills

Phentermine is a prescription drug for diet and is similar in chemical structure to amphetamine, a stimulant used for treatment purposes of attention deficit hyperactivity disorder.

Amphetamine is a commonly abused street drug; hence a person who takes phentermine for diet control could easily fail a drug test due to these similarities.

12. Antidepressants

Antidepressants (TCAs) can lead to false-positive tests for hallucinogenic drug LSD (lysergic acid diethylamide), which have psychological effects on their consumers.

This is because of the 3-ring nucleus of TCAs present in the structure of this class of antidepressants. Many structurally related medications have proven to cross-react with TCAs in either serum or urine immunoassays.

Antihistamine agents have been observed to interfere with the serum immunoassay for TCAs. This reaction results in a breakdown of a byproduct in LSDs, which explains false-positive results for this specific kind of test.

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Furthermore, the standard size container makes it easy to conceal, and it is unisex, so it can be used by both male and female users.

The information on this website about detox products and synthetic urines is for educational purposes only. We do not endorse or condone their illegal use. Always consider the laws in your area and the potential legal consequences. Consult with a healthcare professional before using any products. Your responsibility and well-being are paramount.