What Can Cause a False Positive for Oxycodone

Oxycodone is semi-synthetic opioid analgesic, which means that oxycodone is a narcotic, and it causes dependence (addiction). Oxycodone is used to relieve mild and moderate pain as well as another type of pain known as around-the-clock pain, for which an extended release form of oxycodone is used.

The same as other opioids, such as morphine and methadone, hydrocodone is commonly abused and misused as a recreation drug because of its effects on the central nervous system that results in sedation, for example. Examples of oxycodone brands: Oxaydo, OxyCONTIN, Oxyfast, Roxicodone and Xtampza ER.

What Can Cause a False Positive for Oxycodone

Over the counter cough suppressants and ibuprofen

  • Hydrocodone-containing drugs, such as Hysingla ER, Zohydro ER
  • Naltrexone-containing drugs, such as Vivitrol, Revia, Depade
  • Doxylamine-containing drugs, such as Unisom
  • Hydromorphone-containing drugs, Such as Dilaudid, Dilaudid-5, and Exalgo
  • Cough suppressants containing dextromethorphan, such as Robitussin CoughGels, Delsym, Buckleys Mixture, Creomulsion, Creo-Terpin, DayQuil Cough, Elixsure Cough, Robafen Cough Liquidgels, Scot-Tussin Diabetic, Silphen DM, Sucrets DM Cough, Theraflu Thin Strips Cough, and Triaminic Long Acting Cough

Why Do Those Drugs Cause A False Positive

The majority of drug tests lack specificity. Thus, such tests detect Oxycodone in the system through certain types of assays, which are not able to specifically detect Oxycodone or its metabolites.

Instead, those tests depend on a structure-based technique that detects not only oxycodone-containing drugs and their metabolites; but also all drugs having structures similar to those of Oxycodone, causing a false positive for oxycodone.

How Long Can Those Drugs Cause A False Positive

As long as those drugs or their metabolites are still in your system, they are likely to cause a false positive for Oxycodone.

Importantly, other factors can significantly affect the false positive results of Oxycodone’s tests. Those factors differ from a person to another, including:

  • your age
  • your body mass
  • The administered dosage. For example, an overdose of any of the previously mentioned drugs will undoubtedly take a longer time to be cleared from the body.
  • Whether you’re a light or a chronic user of the previous drugs.
  • Your metabolic rate of drugs, which determines how quickly your body can get rid of the previous drugs.
  • The type of tests you are required to undergo, as well as the time the test is performed. Each test has a certain time frame to detect certain drugs.


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